Cholinergic Vs anti-cholinergic:
Cholinergic neurotransmitter:
- Acetylcholine (Ach ) binds to the specific cholinergic receptors to show it's action .
- Muscurinc receptors (M1, M2, M3 , M4 , M5) this receptors located at different organs and tissues.
- Nicotinc receptors ( Nn , Nm) .
- Cholinomimetics drugs are mainly classified as direct acting and indirect acting cholinomimetics.
- Direct acting produced it's effect by direct binding to the cholinergic receptors and mimetic the Ach action .
- Indirect acting ; produce it's effect by inhibiting the enzyme Actylcholinesrease (AchE) ,that responsible for Ach degradation.
Cholinergic Agonist :
Examples for some agents ;
- Acetylcholine
- Neostigmine
- Physostigmine
- carbacol
Cholinergic antagonist :
Examples for some agents ;
- Atropine
- Hyoscin - scoplamine
- oxybutynin
- Atropine like effect drugs .
Cholinergic agonist common side effects :
- Salivation
- bradycardia / decreases heart rate
- Decreases the blood pressure / cause Hypotension .
- Bronchospasm / might be fatal with asthma people .
- Urination .
- Ulcer.
Common side effects of Atropine :
- Dry muoth.
- tachycardia / increases the heart rate.
- Increases in blood pleasure / Hypertension .
- Urinary retention .
Uses of cholinergic agonists :
- its used in the treatment of Mystina gravies .
- Used as post operation urinary retention .
- Used in the treatment of atropine overdose .
- Used in the treatment of curare poisoning / over does .
Uses of Atropine / like drugs :
- Asthma treatment
- GIT upset .
- Parkinson disease .
- Ulcer treatment .
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